NIH:OVCAR-3 nuclear extract
Active Motif's NIH:OVCAR-3 nuclear extract was prepared from cell cultures of the human ovarian carcinoma NIH:OVCAR-3 cell line. The NIH:OVCAR-3 cell line was derived from malignant ascites of a 60 year old Caucasian female patient with progressive adenocarcinoma of the ovary who underwent combination chemotherapy treatment with cyclophosphamide, Adriamycin, and cisplatin. NIH:OVCAR-3 cultured cells are epithelial in morphology and are characterized by the expression of cytoplasmic androgen and estrogen specific receptor molecules. They are tumorigenic in athymic mice and have an abnormal karyotype. These cells are resistant to clinically relevant concentrations of Adriamycin, melphalan and cisplatin chemotherapies. NIH:OVCAR-3 cells are most commonly used in research as a model for ovarian carcinoma and to study the efficacy of hormone cancer therapies.