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MALT1 antibody (mAb), sample

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for MALT1 antibody (mAb)Application Notes


Validated Applications:
WB: 0.5 - 2 µg/ml dilution

for MALT1 antibody (mAb)Immunogen

This MALT1 antibody was raised against a recombinant protein corresponding to amino acids 701-808 of mouse MALT1.

for MALT1 antibody (mAb)Buffer

Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.

for MALT1 antibody (mAb)References

 
MALT1 antibody (mAb) tested by Western blot.

MALT1 mAb tested by Western blot.
MALT1 detection by Western blot. The analysis was performed using 20 µg Jurkat nuclear extract and MALT1 mAb at a 2 µg/ml dilution.

for MALT1 antibody (mAb)Background

MALT1 enhances Bcl10-induced activation of NF?B and is also involved in nuclear export of Bcl10. MALT1 binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. MALT1 dependent Bcl10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. MALT1 was independently identified as a protein of 824 amino acids, and human MALT2 isoform b is an amino acid protein of 813 amino acids. MALT1 is thought to play a role in NF?B signaling by enhancing NF?B (NF?B p50 and NF?B p65) activation through interaction with Bcl10. Interaction between MALT1 and Bcl10 mediates IKK (IKK?, IKK? Clone 10AG2, IKK? Clone 10A9B6, IKKi/IKK? and IKK?) activation in vitro through facilitating the ubiquitination of NEMO by the ubiquitin conjugating enzyme UBC13.

for MALT1 antibody (mAb)Positive Control

Active Motif's Jurkat nuclear extract (Catalog No. 36014) can be used as a positive control for MALT1 antibody.

for MALT1 antibody (mAb)Storage

Some products may be shipped at room temperature. This will not affect their stability or performance. Upon receipt, unconjugated antibodies may be stored at -20°C for up to 2 years. Fluorophore- & enzyme-conjugated antibodies should be stored at 4°C. Fluorophore-conjugated antibodies should be protected from light. Keep reagents on ice when not in storage; to avoid repeated freeze/thaw cycles, we recommend aliquoting items that will be stored frozen into single-use fractions prior to freezing.

for MALT1 antibody (mAb)Guarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.

Application Key

  • ChIP = Chromatin Immunoprecipitation;
  • DB = Dot Blot;
  • ELISA = Enzyme-linked Immunosorbent Assay;
  • EMSA = Electrophoretic Mobility Shift Assay
  • FC = Flow Cytometry;
  • ICC = Immunocytochemistry;
  • IF = Immunofluorescence;
  • IHC = Immunohistochemistry;
  • IP = Immunoprecipitation;
  • MeDIP = Methyl-DNA Immunoprecipitation;
  • TR-FRET = Time-Resolved Fluorescence Resonance Energy Transfer;
  • WB = Western Blotting