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MTA2 antibody (pAb), sample

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for MTA2 antibody (pAb)Application Notes

Validated Applications:
WB: 1:500 - 1:2,000 dilution

for MTA2 antibody (pAb)Immunogen

This MTA2 antibody was raised against a peptide corresponding to the C-terminus of human MTA2.

for MTA2 antibody (pAb)Buffer

Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.

for MTA2 antibody (pAb)References

MTA2 antibody (pAb) tested by Western blot.

MTA2 pAb tested by Western blot.
Nuclear extract (25 µg) of HEK293 (Lane 1) and CSML0 cells (Lane 2) was probed with MTA2 pAb (1:2,000).

for MTA2 antibody (pAb)Background

MTA2 (Metastasis-associated protein 2) is a member of the Mi-2/NuRD complex, a nucleosome (chromatin) remodeling deacetylase complex. The MTA family sequences contain several common domains, potentially involved in protein-protein interactions (BAH domain), in DNA binding (SANT domain and GATA-type zinc finger motif) and in signal transduction involving many kinase, adaptor and scaffolding proteins (src-homology (SH)-binding motifs). Tumor suppressor p53 protein is deacetylated by both MTA1 and MTA2, leading to inhibition of growth arrest in transforming cells supporting a link between these protein family members and metastasis. MTA2 is ubiquitously expressed.

for MTA2 antibody (pAb)Positive Control

Active Motif's 293 nuclear extract (Catalog No. 36033) can be used as a positive control for MTA2 antibody.

for MTA2 antibody (pAb)Storage

Some products may be shipped at room temperature. This will not affect their stability or performance. Upon receipt, unconjugated antibodies may be stored at -20°C for up to 2 years. Fluorophore- & enzyme-conjugated antibodies should be stored at 4°C. Fluorophore-conjugated antibodies should be protected from light. Keep reagents on ice when not in storage; to avoid repeated freeze/thaw cycles, we recommend aliquoting items that will be stored frozen into single-use fractions prior to freezing.

for MTA2 antibody (pAb)Guarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.

Application Key

  • ChIP = Chromatin Immunoprecipitation;
  • DB = Dot Blot;
  • ELISA = Enzyme-linked Immunosorbent Assay;
  • EMSA = Electrophoretic Mobility Shift Assay
  • FC = Flow Cytometry;
  • ICC = Immunocytochemistry;
  • IF = Immunofluorescence;
  • IHC = Immunohistochemistry;
  • IP = Immunoprecipitation;
  • MeDIP = Methyl-DNA Immunoprecipitation;
  • TR-FRET = Time-Resolved Fluorescence Resonance Energy Transfer;
  • WB = Western Blotting