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for 2'-Deoxy-5-fluorocytidineChemical Properties

MW = 245.2
CAS 10356-76-0
MP = 196°C
>98% (TLC); NMR (Conforms)

for 2'-Deoxy-5-fluorocytidineDescription

A DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors (ref 1). Like 5-Azacytidine and decitabine, 2'-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation (ref 2). It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways (ref 3). It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo (ref 4).

for 2'-Deoxy-5-fluorocytidineContents

White solid. May be dissolved in DMSO (20 mg/ml).

for 2'-Deoxy-5-fluorocytidineStorage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.

for 2'-Deoxy-5-fluorocytidineReferences

1. J Ren et al. Cell Signal. 2011, 23:1082
2. H Gowher et al. Cancer Biol. Ther. 2004, 3:1062
3. Q Zhao et al. Springerplus 2002, 1:65
4. Y Kumaki et al. Antiviral Res. 2011, 92:329

Chemical structure of 2'-Deoxy-5-fluorocytidine.

Chemical structure of 2'-Deoxy-5-fluorocytidine.