Control Ab, Anti-4-1BB
4-1BB (CD137/TNFRSF9), a member of the tumor necrosis factor receptor superfamily, is an inducible co-stimulatory receptor expressed on T cells, NK cells and innate immune cell populations (4). When present on the cell surface, 4-1BB interacts with 4-1BB ligand (4-1BBL), and induces subsequent cell proliferation and production of interferon gamma (IFNγ) and IL-2, particularly in T and NK cells. Control Ab, Anti-4-1BB, is a mouse anti-human 4-1BB agonist antibody. It can be used as a positive control in the 4-1BB Bioassay in the presence of FcgRIIb CHO-K1 Cells (Cat.# JA2251, JA2255).