Control Ab, Anti-LAG-3
LAG-3 is an immune checkpoint receptor expressed on activated CD4+ and CD8+ T cells and natural killer (NK) cells and plays a critical role in regulating immune responses to tumor antigens and autoantigens. Engagement of LAG-3 by its best characterized ligand, major histocompatibility complex II (MHCII), inhibits TCR signaling, cytokine production and proliferation of activated T cells. Therapeutic antibodies designed to block the LAG-3/MHCII interaction show promising results in clinical trials for the treatment of a variety of cancers. Control Ab, Anti-LAG-3 is a control antibody for blocking LAG-3 for use with the LAG-3/MHCII Blockade Bioassay, a biologically relevant MOA-based assay that can be used to measure the potency and stability of antibodies and other biologics designed to block the LAG-3/MHCII interaction.