As we approach the Christmas & New Year period, we’d like to notify you of our final date for receiving routine orders to facilitate delivery before the Christmas break as Friday 15th December 2023.
The MyBio Team would like to take this opportunity to thank you for your business and continued support. We look forward to meeting you again in 2024.
Active Motif's Embelin inhibits the lysine acetyltransferase PCAF in vitro and in vivo (in vitro IC50 = 7.2 uM). It inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, and H4K12 unchanged. It also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 uM, competing with Smac peptide). Embelin to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. It induces apoptosis and alters gene expression profiles in breast cancer cells. Embelin possesses anti-inflammatory and analgesic activity in vivo, and it is cell permeable.
