ICOS Blockade Bioassay 5X

The ICOS Blockade Bioassays are bioluminescent cell-based assays used to measure the potency and stability of ligands or antibodies that bind and block ICOS/ICOSL. ICOS (CD278) binds to its ligand ICOSL (B7-H2, CD275), which is constitutively expressed on B cells, monocytes and dendritic cells, and can be induced on endothelial and epithelial cells during inflammation. ICOS co-stimulation induces the production of effector T cell cytokines such as interferon (IFN)-gamma, interleukin (IL)-4 and IL-10.The ICOS Blockade Bioassay reflects the mechanism of action (MOA) of biologics designed to block the interaction of ICOS with its ligand, ICOSL.