Promega forensic products are manufactured in alignment with the ISO 18385 standard. This standard ensures minimal risk of human DNA contamination for products used to collect, store and analyze biological materials for forensic purposes. Learn more at: www.promega.com/products/genetic-identity/forensic-grade-faq/. The PowerPlex Fusion 6C System is a 27-locus multiplex for human identification applications including forensic analysis, relationship testing and research use. This six-color system allows co-amplification and fluorescent detection of the 18 autosomal loci in the expanded CODIS core loci (CSF1PO, FGA, TH01, vWA, D1S1656, D2S441, D2S1338, D3S1358, D5S818, D7S820, D8S1179, D10S1248, D12S391, D13S317, D16S539, D18S51, D19S433 and D21S11) and Amelogenin and DYS391 for gender determination. The Penta D, Penta E, TPOX, D22S1045 and SE33 loci also are included to increase discrimination and allow searching of databases that include profiles with these loci. Finally, two rapidly mutating Y-STR loci, DYS570 and DYS576, are included in the multiplex. The PowerPlex Fusion 6C System works well with extracted DNA samples, including low amounts of template DNA, mixtures and inhibitor-laden samples. The PowerPlex Fusion 6C System is also compatible with direct amplification, enabling streamlined STR databasing efforts. Amplification can be successfully performed with sample types such as FTA card punches as well as pretreated swabs, Bode Buccal DNA Collector punches or S&S 903 punches. Fast cycling conditions used with the PowerPlex Fusion 6C System reduce sample-processing time for all samples. The PowerPlex Fusion 6C System is compatible with the Applied Biosystems 3500 and 3500xL Genetic Analyzers as well as Applied Biosystems 3130 and 3130xl Genetic Analyzers with Data Collection Software Version 4.0 with the DC v4 6-Dye Module v1 License (Life Technologies).