Phorbol 12-myristate 13-acetate (PMA) is a specific activator of group A (?, ?I, ?II, ?) and group B (?, ?, ?, ?) Protein Kinase Cs (PKCs) (in the 1–100nM range). Phorbol esters, such as PMA, affect PKCs by mimicking diacylglycerol, a natural ligand and activator of PKCs. PMA is an effective skin irritant and potent tumor promoter in mice. A common alternative name for PMA is 12-O-tetradecanoylphorbol 13-acetate (TPA). The chemical identity and purity of PMA are confirmed by proton NMR.
Supplied as a dried material. Resuspend 5mg in 1.62ml of DMSO to produce a stock solution of 5mM.
Certificate of AnalysisLookup Certificate of Analysis
-30C TO -10C
For Research Use Only. Not for Use in Diagnostic Procedures.