Recombinant c-Myc / MAX complex
c-Myc (MYC Proto-Oncogene, BHLH Transcription Factor), also known as MYCC or MRTL, is a transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Diseases associated with MYC include Burkitt Lymphoma and Precursor T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and IL-2 Pathway. c-Myc can activate the transcription of growth-related genes. MAX (MYC Associated Factor X), also known as BHLHd4, is a member of transcription regulators. MAX forms a sequence-specific DNA-binding protein complex with MYC or MAD, and the MYC / MAX complex is a transcriptional activator, whereas the MAD / MAX complex is a repressor. It may repress transcription via the recruitment of a chromatin remodeling complex containing H3 Lys-9 histone methyltransferase activity. c-Myc / MAX complex can specifically recognize the core sequence 5-CAC[GA]TG-3 and bind to the E box DNA consensus sequence and regulates the transcription of specific target genes.