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Zebularine
Active Motif€ 0.00Active Motif's Zebularine is a DNA methyltransferase inhibitor which binds covalently to methyltransferases. Zebularine re-activates silenced E-cad...
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UNC1999
Active Motif€ 0.00Active Motif's UNC1999 is an orally active, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50 =...
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UNC-2170
Active Motif€ 0.00Active Motif's The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a ...
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Tubastatin A hydrochloride
Active Motif€ 0.00Active Motif's Potent and selective histone deacetylase 6 (HDAC 6) inhibitor (IC50 = 15 nm; >1000-fold selective against other HDACs and 60-fold...
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Triacetyl resveratrol
Active Motif€ 0.00Active Motif's Triacetyl resveratrol is a resveratrol prodrug. One method for increasing the half-life of resveratrol in vivo is acetylation of the...
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TC-E-5003
Active Motif€ 0.00Active Motif's TC-E-5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 uM). It displays no activity against CAR...
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Splitomicin
Active Motif€ 0.00Active Motif's Splitomicin is a Sirtuin inhibitor that was initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phen...
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SirtAct
Active Motif€ 0.00Active Motif's SirtAct is a sirtuin activator (Sirt1). It suppressed TNF-alpha release from THP-1 cells and stimulated adipogenesis in 3T3L1 cells....
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Sinefungin
Active Motif€ 0.00Active Motif's Sinefungin is a Nucleoside S-adenosyl-1-methionine analog. It is a potent, competitive methyltransferase (protein, DNA, and RNA meth...
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SGC707
Active Motif€ 0.00Active Motif's SGC707 is a potent and selective allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3), IC50 = 31 nM and selective ag...
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Salermide
Active Motif€ 0.00Active Motif's Salermide is a SIRT1 and SIRT2 inhibitor. It exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Salermide induce...
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RVX-208
Active Motif€ 0.00Active Motif's RVX-208 is a potent BET bromodomain antagonist with (IC50 = 0.51 uM for BD2) with approximately 170-fold selectivity over BD1 (ref 1...
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RG108
Active Motif€ 0.00Active Motif's RG108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM). It inhibits DNA methylation in human and tumor cell lines...
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PBIT
Active Motif€ 0.00The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases is responsible for demethylation of trimethylated lysine 4 in histo...
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NSC-663284
Active Motif€ 0.00Active Motif's NSC-663284 is a potent and selective inhibitor of the protein lysine methyltransferase SETD8 (IC50 = 0.21 uM) which efficiently supp...
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Mocetinostat
Active Motif€ 0.00Active Motif's Mocetinostat is a Class I, isoform-selective HDAC inhibitor (IC50 = 0.15, 0.29, 1.66 and 0.59 uM for HDAC1, 2, 3 and 11 respectively...
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ML-324
Active Motif€ 0.00Active Motif's ML-324 inhibits JMJD2 histone demethylases (JMJD2 IC50 = 920 nM). It represses the expression of viral (HCMV and HSV-1) immediate ea...
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Mithramycin A
Active Motif€ 0.00Active Motif's Mithramycin A inhibits DNA methyltransferase. A selective Sp1 inhibitor, it binds to GC-rich DNA sequences, displacing Sp1 transcrip...
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JIB-04
Active Motif€ 0.00Active Motif's JIB-04 is a novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. ...
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GSK-J4 (cell permeable)
Active Motif€ 0.00Active Motif's GSK-J4 is an inhibitor of the histone demethylase JMJD3/UTX. It inhibits demethylation of histone H3K27. GSK-J4 reduces LPS-induced ...
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Embelin
Active Motif€ 0.00Active Motif's Embelin inhibits the lysine acetyltransferase PCAF in vitro and in vivo (in vitro IC50 = 7.2 uM). It inhibits H3K9 acetylation in mo...
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