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Inhibitors

  • TM-2-51 - MyBio Ireland - Active Motif

    TM-2-51

    Active Motif
    from € 60.00

    from € 60.00
  • Sodium phenylbutyrate - MyBio Ireland - Active Motif
    from € 35.00
  • Romidepsin - MyBio Ireland - Active Motif

    Romidepsin

    Active Motif
    from € 60.00

    from € 60.00
  • Zebularine - MyBio Ireland - Active Motif

    Zebularine

    Active Motif
    from € 75.00

    Active Motif's Zebularine is a DNA methyltransferase inhibitor which binds covalently to methyltransferases. Zebularine re-activates silenced E-cad...

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    from € 75.00
  • UNC1999 - MyBio Ireland - Active Motif

    UNC1999

    Active Motif
    from € 60.00

    Active Motif's UNC1999 is an orally active, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50 =...

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    from € 60.00
  • UNC-2170 - MyBio Ireland - Active Motif

    UNC-2170

    Active Motif
    from € 75.00

    Active Motif's The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a ...

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    from € 75.00
  • Tubastatin A hydrochloride - MyBio Ireland - Active Motif

    Tubastatin A hydrochloride

    Active Motif
    from € 110.00

    Active Motif's Potent and selective histone deacetylase 6 (HDAC 6) inhibitor (IC50 = 15 nm; >1000-fold selective against other HDACs and 60-fold...

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    from € 110.00
  • Triacetyl resveratrol - MyBio Ireland - Active Motif

    Triacetyl resveratrol

    Active Motif
    from € 65.00

    Active Motif's Triacetyl resveratrol is a resveratrol prodrug. One method for increasing the half-life of resveratrol in vivo is acetylation of the...

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    from € 65.00
  • TC-E-5003 - MyBio Ireland - Active Motif

    TC-E-5003

    Active Motif
    € 75.00

    Active Motif's TC-E-5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 uM). It displays no activity against CAR...

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    € 75.00
  • Splitomicin - MyBio Ireland - Active Motif

    Splitomicin

    Active Motif
    from € 55.00

    Active Motif's Splitomicin is a Sirtuin inhibitor that was initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phen...

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    from € 55.00
  • SirtAct - MyBio Ireland - Active Motif

    SirtAct

    Active Motif
    from € 150.00

    Active Motif's SirtAct is a sirtuin activator (Sirt1). It suppressed TNF-alpha release from THP-1 cells and stimulated adipogenesis in 3T3L1 cells....

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    from € 150.00
  • Sinefungin - MyBio Ireland - Active Motif

    Sinefungin

    Active Motif
    from € 75.00

    Active Motif's Sinefungin is a Nucleoside S-adenosyl-1-methionine analog. It is a potent, competitive methyltransferase (protein, DNA, and RNA meth...

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    from € 75.00
  • SGC707 - MyBio Ireland - Active Motif

    SGC707

    Active Motif
    from € 85.00

    Active Motif's SGC707 is a potent and selective allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3), IC50 = 31 nM and selective ag...

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    from € 85.00
  • Salermide - MyBio Ireland - Active Motif

    Salermide

    Active Motif
    from € 45.00

    Active Motif's Salermide is a SIRT1 and SIRT2 inhibitor. It exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Salermide induce...

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    from € 45.00
  • RVX-208 - MyBio Ireland - Active Motif

    RVX-208

    Active Motif
    from € 95.00

    Active Motif's RVX-208 is a potent BET bromodomain antagonist with (IC50 = 0.51 uM for BD2) with approximately 170-fold selectivity over BD1 (ref 1...

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    from € 95.00
  • RG108 - MyBio Ireland - Active Motif

    RG108

    Active Motif
    from € 55.00

    Active Motif's RG108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM). It inhibits DNA methylation in human and tumor cell lines...

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    from € 55.00
  • PBIT - MyBio Ireland - Active Motif

    PBIT

    Active Motif
    from € 65.00

    The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases is responsible for demethylation of trimethylated lysine 4 in histo...

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    from € 65.00
  • NSC-663284 - MyBio Ireland - Active Motif

    NSC-663284

    Active Motif
    from € 95.00

    Active Motif's NSC-663284 is a potent and selective inhibitor of the protein lysine methyltransferase SETD8 (IC50 = 0.21 uM) which efficiently supp...

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    from € 95.00
  • Mocetinostat - MyBio Ireland - Active Motif

    Mocetinostat

    Active Motif
    from € 85.00

    Active Motif's Mocetinostat is a Class I, isoform-selective HDAC inhibitor (IC50 = 0.15, 0.29, 1.66 and 0.59 uM for HDAC1, 2, 3 and 11 respectively...

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    from € 85.00
  • ML-324 - MyBio Ireland - Active Motif

    ML-324

    Active Motif
    from € 85.00

    Active Motif's ML-324 inhibits JMJD2 histone demethylases (JMJD2 IC50 = 920 nM). It represses the expression of viral (HCMV and HSV-1) immediate ea...

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    from € 85.00
  • Mithramycin A - MyBio Ireland - Active Motif

    Mithramycin A

    Active Motif
    from € 45.00

    Active Motif's Mithramycin A inhibits DNA methyltransferase. A selective Sp1 inhibitor, it binds to GC-rich DNA sequences, displacing Sp1 transcrip...

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    from € 45.00
  • JIB-04 - MyBio Ireland - Active Motif

    JIB-04

    Active Motif
    from € 65.00

    Active Motif's JIB-04 is a novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. ...

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    from € 65.00
  • GSK-J4 (cell permeable) - MyBio Ireland - Active Motif

    GSK-J4 (cell permeable)

    Active Motif
    from € 85.00

    Active Motif's GSK-J4 is an inhibitor of the histone demethylase JMJD3/UTX. It inhibits demethylation of histone H3K27. GSK-J4 reduces LPS-induced ...

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    from € 85.00
  • Embelin - MyBio Ireland - Active Motif

    Embelin

    Active Motif
    from € 55.00

    Active Motif's Embelin inhibits the lysine acetyltransferase PCAF in vitro and in vivo (in vitro IC50 = 7.2 uM). It inhibits H3K9 acetylation in mo...

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    from € 55.00