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DNA damage response (DDR) is a normal cellular function that can result in DNA repair, cell cycle arrest, senescence and/or apoptosis in response to cellular DNA damage. Defects in the DDR pathway lead to genomic instability, cancer initiation and uncontrolled cell proliferation. Many kinases such as WEE1, DNA PK and ATM/ATR in the DDR pathway have been pursued as drug targets for cancer therapy.
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