Enabling Epigenetics Research

Delivering Innovative Tools To Enable Epigenetics & Gene Regulation Research

Active Motif is building a platform based on their patented transposase based technologies to simplify the interrogation of chromatin, the dynamics of histone modifications, chromatin remodeling, DNA methylation, transcription factor binding, as well as short and long range gene regulation by non-coding regulatory regions.

Their bioinformatics platform can take the data generated by these techniques and provide powerful insights into the epigenetic changes occurring in disease or in response to drugs.

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Antibodies

Active Motif's extensive, novel portfolio of monoclonal, polyclonal and AbFlex® recombinant antibodies are validated for the applications you need - chromatin immunoprecipitation (ChIP), ChIP-Seq, Western blot, and Immunofluorescence.

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Recombinant Proteins

Active Motif proteins are manufactured to meet the highest standards of purity and activity required for conventional drug discovery assays, such as HTRF, mass spectrometry, AlphaLISA and Alphascreen.

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ChIP & ChIP-Seq Products

A comprehensive line of products to support all steps in the ChIP workflow, including the largest range of kits and antibodies for ChIP and ChIP-Seq.

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Featured Product

ChIC/CUT&RUN Assay Kit

ChIC/CUT&RUN Assay Kit

CUT&RUN (Cleavage Under Targets & Release Using Nuclease) is an epigenetic method used to investigate the genome-wide distribution of various chromatin-associated proteins and their modifications. CUT&RUN is a derivative of chromatin immunocleavage (ChIC). CUT&RUN is similar to chromatin immunoprecipitation (ChIP), in that it utilizes an antibody to target chromatin-associated marks and proteins, but requires less sample material and less sequencing depths than ChIP. CUT&RUN is compatible with 5,000 to 500,000 cells, and this assay kit is formatted with strip tubes for a more efficient workflow.

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