Recombinant PPARγ protein

PPARg (Peroxisome Proliferator Activated Receptor Gamma), also called as PPARG or NR1C3, is a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. PPAR-gamma is a nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, it can bind to DNA specific PPAR response elements (PPRE) and modulate the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. It's also a key regulator of adipocyte differentiation and glucose homeostasis. PPAR-gamma acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. It plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).