Recombinant EEF1A1 protein
EEF1A1 (Eukaryotic Translation Elongation Factor 1 Alpha 1), also called as LENG7, CTCL Tumor Antigen or CCS3, is an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. EEF1A1 is identified as an autoantigen in 66% of patients with Felty syndrome. EEF1A1 can promote the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, it can form a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. It may also mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress by homocysteine (HC).