Name: Twist Bioscience NGS | Library Preparation | UMI Adapter System
Brand: Twist Bioscience
Availability: InStock

Twist Bioscience Next Generation Sequencing Library Preparation

UMI Adapter System

The Twist UMI Adapter system offers a sensitive method for identifying low frequency somatic variants from cell free DNA (cfDNA). Libraries prepared with the UMI adapter system can be used for building consensus reads during analysis to increase variant detection sensitivity and to reduce PCR error contribution.

Engineered for optimal performance with heterogenous sample types, the system is available in either 16 or 96 sample formats. It contains:

Twist Unique Molecular Identifier (UMI) Adapters - matched unique molecular indices (two for each molecule) that are compatible with 'T-A' overhang workflows.
Twist 10 bp Unique Dual-Indexed (UDI) Primers - Designed with unique dual indices for each mixed primer pair and provided in a 96-well plate format suitable for automation applications.

KEY BENEFITS

High Sensitivity

Matched adapters enable superior identification of PCR errors
Reduces false positives of low frequency variants for cancer research and discovery

Compatible with Twist’s NGS Solutions

Easy integration with Twist Mechanical Fragmentation library prep workflow
Tested for performance with Twist’s target enrichment panels

Appropriate for somatic applications

Accepts gDNA or cfDNA input
Scalable formats for 16 or 96 samples

Compatible with Twist NGS workflows

Twist’s comprehensive NGS toolkit has what you need to take your low input sample from DNA to data. The Twist UMI adapter system integrates seamlessly into existing library preparation workflows, either as a drop-in replacement for Twist Universal adapters or as an additional step.

Greater sensitivity in variant detection

Twist’s UMI adapter system offers a tool for consensus building that removes errors from PCR duplicates.

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PRODUCT SHEET

NGS - Twist UMI Adapter System-Enhanced Sensitivity for rare variant detection - DOWNLOAD

TECHNICAL DOCUMENT

Processing Sequencing Data Utilizing Twist Unique Molecular Identifier (UMI) Adapter System - DOWNLOAD

PROTOCOL

NGS - Library Preparation with the Twist UMI Adapter System - DOWNLOAD
Library Preparation EF 2.0 with Enzymatic Fragmentation and Twist UMI Adapter System - DOWNLOAD
Enzymatic Fragmentation and Twist UMI Adapter System - DOWNLOAD

SKUs

105040 - Twist UMI Adapter System TruSeq Compatible, 16 Samples

105041 - Twist UMI Adapter System TruSeq Compatible, 96 Samples Plate A

105042 - Twist UMI Adapter System TruSeq Compatible, 96 Samples Plate B

105043 - Twist UMI Adapter System TruSeq Compatible, 96 Samples Plate C

105044 - Twist UMI Adapter System TruSeq Compatible, 96 Samples Plate D

105094 - Twist UMI Adapters - TruSeq Compatible, 96 Samples

* For research use only. Not for diagnostic procedures.

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Twist Bioscience NGS | Library Preparation | UMI Adapter System

Twist Bioscience Next Generation Sequencing Library Preparation

UMI Adapter System

KEY BENEFITS

Compatible with Twist NGS workflows

DOWNLOAD

SKUs

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Twist Bioscience NGS | Library Preparation | UMI Adapter System

Twist Bioscience Next Generation Sequencing Library Preparation

UMI Adapter System

KEY BENEFITS

Compatible with Twist NGS workflows

DOWNLOAD

SKUs

Ask a Question or Request a Quote