Twist Bioscience NGS | Alliance Panels | Pan-cancer Methylation Panel

Methylation sequencing is a sensitive tool for detecting and tracing the origin of cancer cells. But like any sequencing project, there is a tradeoff between breadth and depth of coverage. If you’re ready to focus on cancer-specific methylation patterns, this is the panel for you. Experts at AnchorDx partnered with Twist to create a custom target enrichment panel that focuses specifically on targets relevant to 31 different cancers. 

The Twist Alliance Pan-cancer Methylation Panel - 1.5 MB provides deep coverage of clinically focused targets that allow for the study of methylation patterns that may be relevant to early cancer detection and diagnosis from tumor and liquid biopsy samples. Designed in collaboration with experts at AnchorDx and constructed using Twist’s world-class oligonucleotide synthesis platform, this panel provides a high on-target rate and high uniformity, and has been validated with the Twist Methylation workflow using liquid biopsy samples of breast cancer, colorectal cancer, and non-small cell lung cancer.

Interested in seeing which genes are covered? Contact customersupport@twistbioscience.com

Panel Design

• 31 cancer types, 47 disease entities, based on TCGA database
• 13,090 Probes 
• 126k CpG sites involved
• ~12k Differentially Methylated Regions (DMRs)
• 9k of 12k (74%) overlapped with the CpG islands

Note: The Twist Alliance Pan-cancer Methylation Panel - 1.5 MB is not ISO-13485 certified