LightSwitch™ Hypoxia (HIF-1α) Biomarker Set

The LightSwitch Validated Hypoxia (HIF-1 alpha) Pathway Collection is a comprehensive set of sequence-verified, transfection-ready, promoter reporter constructs that can be used to accurately quantify transcriptional activation and repression in response to induction of the hypoxia pathway. These constructs are a subset of the 18,000-member LightSwitch Promoter Reporter GoClone Collection that were selected based on sequence motif analysis, published information and in-house analysis of each promoter's activity using our LightSwitch Luciferase Assay. The Hypoxia (HIF-1a) Biomarker Set contains 8 of the highest responding promoters under our chosen test conditions, as well as the promoters of 2 housekeeping genes; the Hypoxia (HIF-1a) Profiling Plate contains 88 promoter reporter constructs that showed significant activation or repression in response to induction. For more complete information, please visit the Active Motif website.