LightSwitch™ p53 Biomarker Set

The LightSwitch Validated p53 Pathway Collection is a comprehensive set of sequence-verified, transfection-ready, promoter reporter constructs that can be used to accurately quantify transcriptional activation and repression in response to induction of the p53 pathway. These constructs are a subset of the 18,000-member LightSwitch Promoter Reporter GoClone Collection that were selected based on sequence motif analysis, published information and in-house analysis of each promoter's activity using our LightSwitch Luciferase Assay. The p53 Biomarker Set contains 8 of the highest responding promoters under our chosen test conditions, as well as the promoters of 2 housekeeping genes; the p53 Profiling Plate contains 88 promoter reporter constructs that showed significant activation or repression in response to induction. For more complete information, please visit the Active Motif website.