Mithramycin A - MyBio Ireland - Active Motif
Mithramycin A - MyBio Ireland - Active Motif

Mithramycin A


Active Motif's Mithramycin A inhibits DNA methyltransferase. A selective Sp1 inhibitor, it binds to GC-rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibiting their expression. Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis.

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