Sirtinol - MyBio Ireland - Active Motif
Sirtinol - MyBio Ireland - Active Motif


Active Motif's Sirtinol is a selective sirtuin inhibitor that does not effect HDAC1 (IC50 = 131 M, 38 M and 68 M for SIRT1, SIRT2 and Sir2P respectively). It induces apoptotic and autophagic cell death in MCF-7 human breast cancer cell lines and suppresses survivin expression, which correlates with decreased viability in HT29 colon cancer cells. Sirtinol displays pro-inflammatory effects in adipocytes.

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