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Twist Bioscience Synthetic Controls | Infectious Disease | Respiratory Virus Controls

Twist Bioscience Synthetic Controls | Infectious Disease | Respiratory Virus Controls

Twist Bioscience Synthetic Controls - Infectious Disease 

Twist Synthetic Viral Controls

  1. Monkeypox Controls
  2. SARS-CoV2 Controls
  3. Respiratory Virus Controls

Trusted, accurate and safe controls for a wide-range of applications

The recent Coronavirus pandemic has led to the unprecedented need for diagnostic tests for detecting the presence of SARS-CoV-2 and other Respiratory viruses in a variety of sample types. To address this need, laboratories around the world need high quality tools to enable them in catering to this rapidly expanding requirement for testing.

Reproducible, Quality Results

Positive controls provide quality control measures for a wide range of applications from diagnostic assay development to day-to-day testing. This includes the verification and validation of diagnostic tests of both next-generation sequencing (NGS) and reverse transcription polymerase chain reaction (RT-PCR) assays.

A Safe and Effective Alternative to “Live Virus”

Controls based on viral nucleic acids extracted from either an infected patient or from live virus propagated in cell culture have safety and security concerns. Synthetic controls created through gene synthesis broaden access across diverse strains while mitigating risk.

Flexible formats for your applications

Choose from Standard, Assay Ready, or Encapsuled Control formulations. The standard format provides the controls at high concentration in a frozen liquid formulation. The Assay Ready Controls are provided as a dried pellet that increases stability. Just as protein encapsulation of viruses offers more stable molecular storage, Twist’s The Encapsulated Control products leverage a metal capsule sealed around a desiccated pellet to enhance stability of the RNA controls.

Both the Assay Ready and the Encapsulated formulations are single use controls. The Assay Ready format allows for shipping at ambient temperatures and storage in standard freezers. The enhanced stability of the Encapsulated controls enables extended shelf life and both ship and store at room temperature. Ambient shipping reduces cost and increases accessibility for researchers across the globe.

  Standard Controls Assay Ready Controls Encapsulated Controls
Biosafety Level 1 Level 1 Level 1
Storage Temperature: -70°C to -90°C Temperature: -20°C Ambient     
(4°C - 40°C)
Specification Range Approximately 1x10^6 copies/μL Approximately 2x10^6 copies/tube Approximately 50,000 copies/tube
Physical State Frozen liquid Dried pellet Encapsulated dried pellet
Shelf Life 2 years 2 years 5 years
Shipping Dry Ice Ambient Ambient 

Fully synthetic RNA
  • Includes fully synthetic RNA generated from Twist gene fragments
  • Powerful alternative to live viruses

Full viral genome coverage
  • >99.9% viral genome coverage
  • NGS sequence verified
  • Enables versatility in assay design

Versatile controls
  • Positive controls perform for both qPCR and NGS assays
  • Content is well-aligned with Twist target enrichment panels
New Control Variants Cover the Recent Strains That Impact the World

Now available: Variants of Interest and Variants of Concern, see table on SARS-CoV-2 Controls tab

•    Control 14 Alpha (B.1.1.7 lineage) 
•    Control 15 Alpha (B.1.1.7 lineage) 
•    Control 16 Beta (B.1.351 lineage) 
•    Control 17 Gamma (P.1 lineage) 
•    Control 18 Kappa (B.1.617.1 lineage) 
•    Control 19 Iota (B.1.526 lineage)
•    Control 21 Epsilon (B1.1.429 lineage)
•    Control 23 Delta (B.1.617.2 lineage) 
•    Control 24 (B.1.617.3 lineage) 
•    Control 28 Delta (AY.1 lineage) 
•    Control 29 Delta (AY.2 lineage)
•    Control 48 Omicron (B.1.1.529, BA.1 lineage)
•    Control 50 Omicron (B.1.1.529, BA.2 lineage) 
•    Control 51 Omicron (B.1.1.529, BA.2 lineage) 
•    Control 62 Omicron (B.2.12.1 lineage)
•    Control 63 Omicron (B.2.12.1 lineage)

WATCH WEBINAR: Targeted Tools for SARS CoV 2 Research with Mark Consugar and Venkatesh Moktali


The Twist Synthetic Respiratory Virus Controls cover a broad range of RNA and DNA viruses relevant to respiratory disease research. These controls are aligned with the content of the Twist Respiratory Virus Research Panel (PN 103067) and are suitable for use with Twist Fixed Panel NGS workflows or for use with RT-PCR or qPCR experiments of your own design. 

The figure shows a taxonomic tree of viruses covered by the Twist Respiratory Virus Controls. The table shows GenBank IDs, virus type and length for each control. Additional viral controls may be available for custom synthesis. Please contact your local sales representative for more details.

NGS Respiratory Viral Controls Taxonomic Tree

Virus name Genbank IDs, virus type, and lengths

Virus name Genbank IDs, virus type, and length for each virus included in the Twist Respiratory Virus Controls. Additional viral controls may be available for custom synthesis.

NGS Respiratory Viral Controls Part Numbers

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Twist Bioscience Synthetic Controls | Infectious Disease | Respiratory