EEF1A2 (Eukaryotic Translation Elongation Factor 1 Alpha 2), also called as EF1A or Statin, is an isoform of the alpha subunit of the elongation factor-1 complex. This complex is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. There are two isoforms for subunit alpha, EEF1A1 and EEF1A2. EEF1A2 promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer.
