Recombinant NSD2 (MMSET)-SET peptide that includes amino acids 942-1240 that contains the SET domain sequence of the human NSD2 (MMSET)-SET protein (accession number NP_579877.1) was expressed in E. coli cells and contains an N-terminal GST-Tag with an observed molecular weight of 60 kDa. The recombinant protein is >90% pure by SDS-PAGE.