Recombinant YTHDC2 (1279-1429) protein corresponding to amino acids 1279-1429 that contains the YTH domain sequence of human YTHDC2 (accession number NP_073739.3) was expressed in E. coli cells with an N-terminal 6×His tag and a C-terminal Flag tag. The molecular weight of the protein is 22.2 kDa.