As we approach the Christmas & New Year period, we’d like to notify you of our final date for receiving routine orders to facilitate delivery before the Christmas break as Friday 15th December 2023.
The MyBio Team would like to take this opportunity to thank you for your business and continued support. We look forward to meeting you again in 2024.
ALKBH8 (AlkB Homolog 8), also called as ABH8 or TRMT9A, is a S-Adenosyl-L-Methionine-dependent tRNA methyltransferase. It catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. It was reported to have a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). ALKBH8 can bind tRNA and catalyze the iron and alphaketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine. It is also required for normal survival after DNA damage. ALKBH8 may inhibit apoptosis and promote cell survival and angiogenesis.