METTL7B (Methyltransferase-Like Protein 7B) was originally identified as a Golgi-associated methyltransferase and is S-adenosylmethionine-dependent. It is associated with a lot of diseases including Muscular Dystrophy, Congenital, Due To Integrin Alpha-7 Deficiency and Supraglottis Cancer. Previous work has shown that RhoBTB1 regulates the integrity of the Golgi complex through METTL7B. RhoBTB1 is required for expression of METTL7B and silencing of either protein leads to fragmentation of the Golgi.
