TRIT1 (tRNA Isopentenyltransferase 1), also called as IPTase or MOD5, is a highly conserved tRNA isopentenyl transferase that modifies a subset of tRNAs in human cells. It is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. TRIT1 is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional.
